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KMID : 0363619990200020128
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Journal of Korean Oriental Medicine
1999 Volume.20 No. 2 p.128 ~ p.140
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Study on Antitumor and Antimetastatic Effects of Samyongbakchulsankamibang
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Kim Sung-Hoon
Jeon Ki-Seok
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Abstract
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To evaluate the antitumor activity, antimetastatic and immunomodulatory effects of samryongbakchulsankamibang(SBSK) studies were done experimentally, In cytotoxicity against P388, A549. SK-OV-3, B16-F10 and SK-MEL-2. concentration inhibiting cell growth up to below 40% of control was recognized at 10^{-3}g/ml of SBSK. In Inhibitory effect on activity of DNA topoisomerase I. the IC_{50} was shown 200-400{mu}g/ml of SBSK. The T/C was 154% in SBSK-treated group in S-180 bearing ICR mice, The concentration inhibiting adhesion of A549 and B16-F10 to complex extracellular matrix up to below 30% of control was recognized at 5{times}10^{-4}, 1{times}10^{-3};g/ml of SBSK. In pumonary colonization assay with B16-BL/6, a number of colonies in the lungs were decreased significantly in SBSK-treated group as compared with control group, In hematological changes in B16-BL/6 injected C57BL/6, numbers of WBC and platelet were not changed significantly in SBSK-treated groups, In CAM and in vitro neovascularization assay, angiogenesis was inhibited significantly in SBSK-treated group as compared with control group. From above results it was concluded that SBSK could be usefully applied for the prevention and treatment of cancer.
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KEYWORD
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Samyongbakchulsankamibang, DNA topoisomerase-I, pulmonary colonization assay, T/C%, Chorioallantoic membrane assay
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